the AMERICAN SOCIETY for MICROBIOLOGY
A conference on "Microbial
Evolution and Genomics"
will be held at MICHIGAN STATE UNIVERSITY
East Lansing, Michigan on Saturday,
by faculty members and students of the
of MICROBIOLOGY AND MOLECULAR GENETICS
Michigan ASM extends a special invitation to our colleagues in
to join us for this one-day conference at Michigan
our Speakers . . .
Foundation Speaker is DR.
CLAIRE M. FRASER, Director
and President of The Institute for Genomic Research. Dr.
Fraser will address the topic: "Microbial
completion of more than 20 microbial genome sequencing projects has provided
a new starting point for understanding microbial biology, the interaction
of pathogens and hosts, and the evolution of microbial species.
FRASER is President and Director of The Institute for Genomic Research
(TIGR) in Rockville, MD. She was
formerly the Director of the Department of Microbial Genomics and Vice-President
of Research at TIGR. TIGR is devoted to the sequencing and functional analysis
of human, animal, plant, and microbial genomes to better understand the
role that genes play in development, evolution, physiology and disease.
She earned her B.S. from Rensselaer
Polytechnic Institute and her Ph.D. from State University of New York at
Buffalo. Throughout much of her early career, Dr. Fraser's interests focused
on the structure and function of G protein-coupled receptors. At TIGR,
she was initially involved in studies to elucidate differences in gene
expression in human tumors and matched normal tissues and in using a genomic-based
approach to understand the molecular basis of tumor development. More recently,
Dr. Fraser has been involved in whole genome sequence analysis of microbial
genomes, leading the teams that sequenced the genomes of Mycoplasma
genitalium, the smallest genome of any known free-living organism,
the two spirochetes, Treponema pallidum and Borrelia burgdorferi,
and two species of Chlamydia.
Dr. Fraser has over 130 publications
in leading scientific journals, is a reviewer for nine journals, has edited
two volumes in the Receptor Biochemistry and Methodology series
on neurotransmitter receptors, was previously an editor for the International
Encyclopedia of Pharmacology and Therapeutics, and is currently serving
on the Editorial Board of The Journal of Biological Chemistry and Comparative
and Microbial Genomics. She was selected as one of Maryland's
Top 100 Women in 1997 and was awarded the 1998 Computerworld Smithsonian
Award for Innovation in Information Technology and the 1999 IMAS Award
from The Institute for Mathematics and Advanced Supercomputing for outstanding
achievements in the field of algorithms and their computer implementation.
Richard Lenski,Hannah Professor, Department of Microbiology
and Molecular Genetics at Michigan State University, will speak on: "DYNAMICS
OF PHENOTYPIC AND GENOMIC EVOLUTION: A 20,000-GENERATION EXPERIMENT WITH
LENSKI earned a BA from Oberlin College and his Ph.D. in 1982 from
the University of North Carolina, Chapel Hill. He was an Associate Professor
at University of California - Irvine before taking his current Hannah Professorship
at MSU in 1991. Dr. Lenski is a Fellow of the American Academy of Microbiology
and was a 1996 MacArthur Fellow. He has over 130 publications in a wide
variety of prestigous journals, including PNAS, Nature, Evolution, Science,
and Microbial Ecology.
From his web site, Rich tells
us: "I am interested in the ecological processes and genetic mechanisms
that cause evolutionary change. I study microorganisms in order to take
advantage of their rapid generations and large populations, which make
it feasible to test evolutionary hypotheses by direct
"In one project that has been
on-going for more than ten years, my students and I are
studying the adaptation and divergence
of bacterial populations, while they evolve in a
defined laboratory environment
for more than twenty-thousand generations. We seek to
understand the dynamics of these
evolutionary processes as well as the ecological,
physiological, and genetic changes
that are responsible for the substantial gains in fitness that
"In other projects, we use bacteria
and the viruses and plasmids that infect them as model
systems for studying the ecology
and evolution of host-parasite interactions. Yet other
projects are concerned with the
spread of antibiotic resistance, the evolution of mutation
rates, the form and extent of
interactions among mutations, life in variable environments, and
costs and benefits of primitive
sociality in bacteria."
Thomas S. Whittam, Hannah
Professor, Department of Microbiology and Molecular Genetics at Michigan
State University and faculty member of the National
Food Safety and Toxicology Center at MSU. Dr. Whittam will speak on
MOLECULAR EVOLUTION OF BACTERIAL PATHOGENS".
WHITTAM earned his BA from Franklin & Marshall College and his
Ph.D. in 1981 from the University of Arizona. From his web site, he tells
us about his research interests:
of Bacterial Populations
Bacteria are a difficult and
challenging problem for population geneticists. The difficulty arises because
in nature bacteria reproduce asexually and recombine only occasionally
through mechanisms of gene transfer. As a consequence, different species
exhibit a range of population structures from clone mixtures to freely
recombining populations similar to biological species of higher organisms.
Often the amount of recombination in nature is intermediate - too much
for a purely phylogenetic approach
and too little to assume "random
assortment." One of my main research interests has been the study of the
genetic structure of natural populations of bacteria using molecular polymorphisms
and the development of statistical methods for assessing recombination.
of pathogenic forms of E. coli
Although E. coli is normally
a harmless organism in the human gut, certain strains are pathogens that
have caused serious outbreaks of infectious disease. A major research effort
in my laboratory has been the study of the evolution of pathogenic forms
of E. coli associated with intestinal and extra-intestinal infections.
Through the analysis of molecular polymorphisms, we are testing evolutionary
hypotheses regarding the major genetic events leading to the origin of
new pathogens. We have elucidated the ancestry of a new type of food-borne
pathogen, Escherichia coli O157:H7, which causes hemorrhagic colitis.
In addition, we have investigated, in collaboration with microbiologists
from other countries, the global distribution of bacterial clones and the
dispersion of specific virulence genes in human populations and animal
evolution of pathogen virulence and host resistance
Recently developed evolutionary
theory shows that natural selection can favor intermediate levels of parasite
virulence depending on the relationship between transmissibility and the
parasite�s effect on host mortality. We are studying the evolution of virulence
experimentally using a microbial host-parasite system. The parasite is
Legionella pneumophila, the bacterium that causes Legionnaires disease.
In nature, Legionella invade and multiply intracellularly in amoeba and
other protozoan hosts. By
propagating host�parasite genotypes
for hundreds of generations we are measuring the direction and rate of
evolution in virulence and changes in host resistance from the ancestral
MICROARRAY WORKSHOP (facilitated
by Dr. Paul
Coussens, Associate Professor of Animal Science and Microbiology
and Molecular Genetics). The workshop is limited
to 30 participants.
The workshop will be conducted by members of Dr. Coussen�s Microarray Facility: Sue Sipkovsky, Steve Suchyta, and Jianbo Yao.
TOUR OF THE BIOMEDICAL & PHYSICAL SCIENCES BUILDING.
For those who are not attending the DNA Microarray workshop, Dr. Jerry Dodgson has arranged for a tour of the new facility. This building houses the Departments of Microbiology and Molecular Genetics, Physiology and Physics. DETAILS OF THE TOUR WILL BE ANNOUNCED AT THE MEETING. The tour will begin shortly after the last speaker in the afternoon. There will also be informal tours of the award-winning horticulture gardens just across the street from the meeting location.
AM Registration, Continental Breakfast, and corporate exhibit &
9:00 AM Welcoming remarks (Dr.
Jerry Dodgson-Chair of the Department of Microbiology and Molecular
Genetics, Dr.Tom Corner-Conference Organizer, Professor Ralph Gorton-MIASM
AM Dr. Claire Fraser, ASM
Waksman Foundation Lecturer; questions
for Dr. Fraser
10:15 AM Brief
AM Dr. Rich Lenski; questions
for Dr. Lenski
- 12:15 PM Visit Corporate Vendors and Student Posters; chat
PM - 1:15 PM Lunch and Business Meeting
- 2:15 PM Dr. Tom Whittam; questions
for Dr. Whittam
- 2:30 PM wrap-Up and closing remarks.
+ DNA ARRAY WORKSHOP and BIOMEDICAL FACILITIES TOUR
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LOCATION, MAPS, PARKING and MISC. INFORMATION
The meeting will be held in the new Biomedical
and Physical Sciences Center on the campus of MICHIGAN STATE
UNIVERSITY. This building is denoted as the "Biological Research Center"
on the current MSU map (at G15 1/2).
to view the campus map (then click on the center
panel and locate G 15.5)
HOME OF BERGEY'S
MANUAL: The Biomedical and Physical Sciences Center will
also be the new home of the Bergey's Manual - the world authority
on known microbes. "Having the Bergey Manual puts MSU in a leadership
says Jim Tiedje. "It is the most highly used database of microbial organisms
in the world."
MAP OF LANSING / EAST LANSING
AREA (main roads):
locations (ramps and surface lots) are indicated on the MSU campus map.
On Saturdays, several additional resident parking lots are open to visitors.
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Michigan ASM encourages students (both undergrads and graduate students), as well as faculty and other professional
microbiologists, to present posters at our fall and spring meetings. Ideally a poster presentation would relate to the general
theme of the conference, but that is not a criterion for submission. If
you would like to present a poster of your research at this MI-ASM CONFERENCE,
follow the guidelines below.
who present a poster do not pay the conference registration fee
they also receive one year free membership in MI-ASM. STUDENT ENTRIES will be
judged by branch members and the winner of the "Best Student Poster" will
receive a framed certificate, a copy of Dr. Philipp Gerhardt's classic
text, and a free membership to the National ASM.
Non-students may also
submit posters; simply follow the above guidelines.
your name, college or university you attend, department affiliation, the
full title of your poster, and a brief (200 words) abstract of its content
to the conference organizer. The deadline
for submitting abstracts for posting on this website is April 1. You
may submit abstracts after this date, but they may not be posted prior
to the conference.
a Times Roman 12-pt. font if possible.Type the title first then list the
authors (all capital letters; use an asterisk to denote the person
delivering the poster), then list institutions and short addresses. You
may include e-mail addresses if you wish.
that are generally understood are acceptable.
or italicize scientific names.
submit the above by email to: email@example.com
Send the information within the body of the
e-mail message and not as an attached file.
You will receive electronic confirmation that your poster info arrived
safely from cyberspace! Your poster abstract will automatically be forwarded
to the Conference Organizer, Dr. Tom Corner.
there is sufficient time, we will post early submitted abstracts on this
meeting web site. All poster abstracts will be posted as part of the on-line
you presented your poster at an ASM National Meeting or at another conference,
please note that in your abstract submission.
you have any questions regarding posters, please contact Dr.
Tom Corner .
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further information, contact the conference campus organizer:
Dr. THOMAS R. CORNER
Professor and Associate Chair
Microbiology & Molecular Genetics
178 Giltner Hall
Michigan State University
East Lansing, MI 48824-1101
may also contact the officers of MI-ASM
the branch home page